In the **Cochrane database analysis, it has been shown that Vitamin C, Vitamin E, folate, selenium, zinc, arginine, carnitine, carotenes, coenzyme Q10 and cysteine, which are substances with direct antioxidant effects, are effective through the antioxidative mechanism in various stages of male infertility.

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*References

**Smits RM, Mackenzie-Proctor R, Yazdani A, Stankiewicz MT, Jordan V, Showell MG. Antioxidants for male subfertility.

Cochrane Database Syst Rev 2019; 3: CD007411.

**Wiep de Ligny, Smits RM, Mackenzie-Proctor R, Jordan V, Fleischer K, de Bruin JP, Showell MG. Antioxidants
for male subfertility. Cochrane Database Syst Rev. 2022 May 4;5(5):CD007411.

Vicari E, La Vignera S, Condorelli R, Calogero AE. Endothelial antioxidant administration ameliorates the erectile

response to PDE5 regardless of the extension of the atherosclerotic process.

J Sex Med. 2010;7(3):1247-1253. doi: 10.1111/j.1743-6109.2009.01420.

Shirai M, Hiramatsu I, Aoki Y, et al.. Oral L-citrulline and transresveratrol supplementation improves erectile

function in men with phosphodiesterase 5 inhibitors: a randomized, double-blind, placebo-controlled

crossover pilot study. Sex Med. 2018;6(4):291-296.

Hamidi Madani A, Asadolahzade A, Mokhtari G, Shahrokhi Damavand R, Farzan A, Esmaeili S. Assessment

of the efficacy of combination therapy with folic acid and tadalafil for the management of erectile

dysfunction in men with type 2 diabetes mellitus. J Sex Med. 2013;10(4):1146-1150.

Gallo L, Pecoraro S, Sarnacchiaro P, Silvani M, Antonini G. The daily therapy with L-arginine 2,500 mg and

tadalafil 5 mg in combination and in monotherapy for the treatment of erectile dysfunction: a prospective,

randomized multicentre study. Sex Med. 2020;8(2):178-185. doi: 10.1016/j.esxm.2020.02.003

El-Wakeel LM, Fouad FA, Saleem MD, Saber-Khalaf M. Efficacy and tolerability of sildenafil/l-arginine combination

relative to sildenafil alone in patients with organic erectile dysfunction.

Andrology. 2020;8(1):143-147. doi: 10.1111/andr.12671

Morano S, Mandosi E, Fallarino M, et al.. Antioxidant treatment associated with sildenafil reduces monocyte

activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind,

placebo-controlled study. Eur Urol. 2007;52(6):1768-1774. doi: 10.1016/j.eururo.2007.04.042

Cabello-Verrugio C, Simon F, Trollet C, Santibañez JF. Oxidative stress in disease and aging: Mecha- nisms and
therapies 2016. Oxidative Med Cell Longevity 2016;2017:4310469.
Ratnam DV, Ankola D, Bhardwaj V, Sahana DK, Kumar MR. Role of antioxidants in prophylaxis and the- rapy: A
pharmaceutical perspective. J Controlled Release 2006;113:189–207.
Ko EY, Sabanegh Jr ES, Agarwal A. Male infertility testing: reactive oxygen species and antioxidant ca- pacity.
Fertil Steril 2014;102:1518–27
Caraccio TR, Mofenson HC. Carnitine. J Toxicol Clin Toxicol 2003;41:897
Nohl H, Gille L, Staniek K. The biochemical, pathophysiological, and medical aspects of ubiquinone function. Ann
N Y Acad Sci 1998;854:394–409
Singh K, Jaiswal D. One-carbon metabolism, spermatogenesis, and male infertility. Reprod Sci 2013;20:622–30.
Kumar M, Kumar K, Jain S, Hassan T, Dada R. Novel insights into the genetic and epigenetic paternal contribution
to the human embryo. Clinics 2013;68:5–14.
Longo N, Frigeni M, Pasquali M. Carnitine transport and fatty acid oxidation. Biochim Biophys Acta. 2016 Jan 29.
pii: S0167- 4889(16)30013-1. doi: 10.1016/j.bbamcr.2016.01.023.
Roy VK, Verma R, Krishna A. Carnitine-mediated antioxidant enzyme activity and Bcl2 expression in- volves
peroxisome proliferator-activated receptor-γ coactivator-1α in mouse testis. Reprod Fertil Dev. 2017
Jun;29(6):1057-1063
Hinton B, Snoswell A, Stechell B. The concentration of carnitine in the luminal fluid of the testis and epididymis
of the rat and some other mammals. J Reprod Fertil.1979; 55:105-11.
Shang XJ, Wang LL, Mo DS, Cai HC, Zheng DD, Zhou YZ. Effect and safety of L-carnitine in the tre- atment of

idiopathic oligoasthenozoospermia: a systemicreview. Zhonghua Nan Ke Xue. 2015 Jan;21(1):65-73.
Sinclair S. Male infertility: nutritional and environmental consid-erations. Altern Med Rev. 2000; 5:28-38.
Kobori Y, Suzuki K, Iwahata T, Shin T, Sadaoka Y, Sato R, Nishio K, Yagi H, Arai G, Soh S, Okada H, Strong JM,
Rohdewald
P. Improvement of seminal quality and sexual function of men with oligoastheno- teratozoospermia syndrome
following supplementation with L-arginine and Pycnogenol®. Arch Ital Urol Androl. 2015 Sep 30;87(3):190-3.
Lewis SE, Sterling ESL, Young IS, Thompson W. Comparison of individual antioxidants of sperm and seminal
plasma in fertile and infertile men. Fertil Steril 1997;67:142–7
Song GJ, Norkus EP, Lewis V. Relationship between seminal ascorbic acid and sperm DNA integrity in infertile
men. Int J Androl 2006;29:569–75.
Colagar AH, Marzony ET. Ascorbic Acid in human seminal plasma: determination and its relationship to sperm
quality. J Clin Biochem Nutr 2009;45:144–9
Cyrus A, Kabir A, Goodarzi D, Moghimi M. The effect of adjuvant vitamin C after varicocele surgery on sperm

quality and quantity in infertile men: a double blind placebo controlled clinical trial. Int Braz J Urol 2015;41:230–8.
Lee WJ, Park JY, Lee KU. α-Lipoic acid prevents diabetes mellitus and endothelial dysfunction in diabe- tes-prone
obese rats. Packer L, Sies H (editörs). Oxidative stress and ınflammatory mechanisms in obesity, diabetes and
the metabolic syndrome. Newyork: CRC Press, 2008: 261-89
Haghighian HK, Haidari F, Mohammadi-Asl J, Dadfar M. Randomized, triple-blind, placebo-controlled clinical trial
examining the effects of alpha-lipoic acid supplement on the spermatogram and semi- nal oxidative stress
in infertile men. Fertil Steril 2015;104(2):318-324.

Yahya M Hodeeb, Emad M El-Rewiny, Abdullah M Gaafar, Ahmed N Zayed, Mohamed S Hasan, Mo- hamed L
Elsaie. The effect of alpha lipoic acid supplementation on sperm functions in idiopathic asthenozoospermic
patients: a case-controlled study. Hum Fertil (Camb). 2022 Jan 13;1-9.
Nohl H, Gille L, Staniek K. The biochemical, pathophysiological, and medical aspects of ubiquinone function. Ann
N Y Acad Sci 1998;854:394–409.
Nadjarzadeh A, Shidfar F, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, et al. Effect of Coenzyme Q10
supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind
randomised clinical trial. Andrologia 2014;46:177–83
Lafuente R, González-Comadrán M, Solà I, López G, Brassesco M, Carreras R, Checa MA. Coenzyme Q10 and male
infertility: a meta-analysis. J Assist Reprod Genet 2013;30:1147–56
Lenzi A, Culasso F, Gandini L, Lombardo F, Dondero F. Placebocontrolled, double-blind, cross-over trial of glutathione

therapy in male infertility. Hum Reprod. 1993;8:1657–1662
Brigelius-Flohé R, Traber MG. Vitamin E. function and metabolism. FASEB J 1999;13:1145–55
Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA

fragmentation by oral antioxidant treatment. J Androl 2005;26:349–53.
Kessopoulou E, Powers HJ, Sharma KK, Pearson MJ, Russell JM, Cooke ID, Barratt CL. A double-blind randomized
placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated

male infertility. Fertil Steril 1995;64:825–31.
Geva E, Bartoov B, Zabludovsky N, Lessing JB, Lerner-Geva L, Amit A. The effect of antioxidant treat- ment on
human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril 1996;66:430–4.
Maret W. Zinc and human disease. Met Ions Life Sci. 2013;13:389-414.
Brown, K.H., Wuehler, S.E., Peerson, J.M., 2001. The importance of zinc in human nutrition and estima- tion of the
global prevalence of zinc deficiency. Food and Nutrition Bulletin 22: 113- 125.
Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med. 2008; 14:353-357. Kasperczyk A et al.,
Environmental exposure to zinc and copper influences sperm quality in fertile males.Ann Agric Environ Med.
2016;23(1):138- 43. doi: 10.5604/12321966.1196869.
Zhao J et al. Zinc levels in seminal plasma and their correlation with male infertility: A systematic revi- ew and
meta-analysis. Sci Rep. 2016 Mar 2;6:22386. doi: 10.1038/srep22386.
Omu AE, Dasthi H, Al- Othman S. Treatment of asthenozoospermia with zinc sulphate: andrological,

immunological and obstetric outcome. Eur J Obstet Gynecol Reprod Biol. 1998 Aug;79(2):179-84. Nelson DL, Cox
MM. Lehninger Principles of Biochemistry, 5. Ed-3. Pr, W.H. Freeman and Company, New York; 2008:519.
Mohammadi P, Hassani-Bafrani H, Tavalaee M, Dattilo M, Nasr-Esfahani MH. One-carbon cycle support rescues
sperm damage in experimentally induced varicocoele in rats. BJU Int. 2018 May 11. doi: 10.1111/bju.14385.
Dattilo M, Cornet D, Amar E, Cohen M, Menezo Y. The importance of the one carbon cycle nutritional support in
human male fertility: a preliminary clinical report. Reprod Biol Endocrinol. 2014 Jul 29;12:71.
Ashoori M, Saedisomeolia A. Riboflavin (vitamin B2) and oxidative stress: a review. Br J Nutr (2014) 111(11):1985–
91
Li MC, Chiu YH, Gaskins AJ, Mínguez-Alarcón L, Nassan FL, Williams PL, Petrozza J, Hauser R, Chavarro JE. Men’s
Intake of Vitamin C and β-Carotene Is Positively Related to Fertilization Rate but Not to Live Birth Rate in
Couples Undergoing Infertility Treatment. J Nutr. 2019 Nov 1;149(11):1977-1984. doi: 10.1093/jn/nxz149.
Goszcz K, Deakin SJ, Duthie GG, Stewart D, Leslie SJ, Megson IL. Antioxidants in Cardiovascular The- rapy:

Panacea or False Hope? Front Cardiovasc Med. 2015 Jul 6;2:29.
Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and
zinc sulphate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril.
2002;77 (3):491-8.
Boxmeer JC, Smit M, Utomo E, Romijn JC, Eijkemans MJC, Lindemans J, et al. Low folate in seminal plasma

is associated with increased sperm DNA damage. Fertil Steril. 2009;92(2):548- 556.
Ursini F, Maiorino M, Brigelius-Flohe R, Aumann K.D, Roveri A,Schomburg D,et al. The diversity of glu- tathione
peroxidases. Meth Enzymol. 1995; 252: 38–53
Flohe L. Selenium in mammalian spermiogenesis. Biol Chem 2007;388:987-95
Ibrahim HA, Zhu Y, Wu C, Lu C, Ezekwe MO, Liao SF, et al. Selenium-enriched probiotics improves muri- ne male
fertility compromised by high fat diet. Biol Trace Elem Res 2012;147:251-60.
Noack-Fuller G, De Beer C, Seibert H. Cadmium, lead, selenium, and zinc in semen of occupationally unexposed
men. Andrologia 1993;25:7–12.
Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parame- ters in
infertile men: a double-blind, placebo controlled, randomized study. 

Lee HC, Jeong YM, Lee SH, Cha KY, Song SH, Kim NK, Lee KW & Lee S. (2006) Association study of four

polymorphisms in three folate-related enzyme geneswith non-obstructivemale infertility. Hum Reprod 21, 3162–
3170
Najafipour R, Moghbelinejad S, Aleyasin A, Jalilvand A. Effect of B9 and B12 vitamin intake on semen parameters
and fertility of men with MTHFR polymorphisms. Andrology. 2017 Jul;5(4):704-710 Hemalatha, S., Hari, R.
Fertility enhancing effect of saponin rich butanol extracts of Tribulus terrestris fruits in male albino rats.
IJPCR, 2015;7, 36–43.
Keshtmand, Z., Oryan, Sh., Ghanbari, A., & Khazaei, M. Protective effect of Tribulus terrestris hydroal- coholic
extract against cisplatininduced cytotoxicity on sperm parameters in male mice. Internati- onal Journal of
Morphology, 2014;32, 551–557.
Salgado RM, Marques-Silva MH, Gonçalves E, Mathias AC, Aguiar JG, Wolff P. Effect of oral administra- tion of
Tribulus terrestris extract on semen quality and body fat index of infertile men. Andrologia. 2017 Jun;49(5).
Zhang Y, Wu X, Zhu K, Liu S, Yang Y, Yuan D, Wang T, He Y, Dun Y, Wu J, Zhang C, Zhao Icariin attenuates

perfluorooctane sulfonate-induced testicular toxicity by alleviating Sertoli cell injury and downre- gulating the
p38MAPK/MMP9 pathway. H.Food Funct. 2022 Mar 21;13(6):3674-3689.
Zhao H, Zhao T, Yang J, Huang Q, Wu H, Pan Y, Wang H, Qian Y.Epimedium protects against dyszoosper- mia
in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16. Cell
Death Dis. 2022 Jan 20;13(1):69.
Yao DF, Mills JN. Male infertility: lifestyle factors and holistic, complementary, and alternative therapi- es. Asian J
Androl. 2016 May-Jun;18(3):410-8.
Park HJ, Choe S, Park NC. Effects of Korean red ginseng on semen parameters in male infertility pa- tients:

A randomized, placebo-controlled, double-blind clinical study. Chin J Integr Med. 2016 Jul;22(7):490-5.
Gonzales GF, Ruiz A, Gonzales C, Villegas L, Córdova A. Effect of Lepidium meyenii (Maca) rotos, a Pe- ruvian plant
on spermatogenesis of male rats. Asian J Androl 2001; 3:231-3.
Gonzales GF, Cordova A, Gonzales C, Chung A, Vega K, Villena A. Lepidium meyenii (Maca) impro- ved semen
parameters in adult men. Asian J Androl. 2001 Dec;3(4):301-3.
Alcalde AM, Rabasa J. Does Lepidium meyenii (Maca) improve seminal quality? Andrologia. 2020
Nov;52(10):e13755.
Yuan JP, Peng J, Yin K, Wang JH. Potential health-promoting effects of astaxanthin: a high-value carote- noid
mostly from microalgae. Mol Nutr Food Res 2011; 55: 150-65.
Miki W. Biological functions and activities of animal carotenoids. Pure Appl Chem 1991; 63: 141-6. Dona G, Kozuh
I, Brunati AM, Andrisani A, Ambrosini G, Bonanni G, et al. Effect of astaxanthin on hu- man sperm capacitation.

Mar Drugs 2013; 11: 1909-19.
Andrisani A, Donà G, Tibaldi E, Brunati AM, Sabbadin C, et al. Astaxanthin improves human sperm capacitation
by inducing lyn displacement and activation. Mar Drugs 2015; 13: 5533-51.
Comhaire FH, El Garem Y, Mahmoud A, Eertmans F, Schoonjans F. Combined conventional/antioxidant “Astaxanthin”

treatment for male infertility: a double blind, randomized trial. Asian J Androl 2005; 7: 257-62.
Kumalic SI, Klun IV, Bokal EV, Pinter B. Effect of the oral intake of astaxanthin on semen parameters in patients
with oligo- astheno-teratozoospermia: a randomized double-blind placebo-controlled trial. Radiol Oncol.
2020 Oct 23;55(1):97-105.
Li H, Deng H, Liu H, Zhong A, et al. [L-carnitine-astaxanthin compound nutrients for the treatment of idiopathic
oligospermia and asthenozoospermia: A multicenter clinical observation]. Zhonghua Nan Ke Xue. 2021
Apr;27(4):334-339.
Habib FK, Wyllie MG. Not all brands are created equal: a comparison of selected components of diffe- rent brands
of Serenoarepens extract. Prostate Cancer Prostatic Dis 2004; 7: 195-200.
Colado-Velázquez J III, Mailloux-Salinas P, Medina-Contreras J, Cruz-Robles D, Bravo G. Effect of sere- noarepens
on oxidative stress, inflammatory and growth factors in obese wistar rats with benign prostatic hyperplasia.
Phytother Res 2015; 29: 1525-1531.
Morgia G, Mucciardi G, Galì A, Madonia M, Marchese F, Di Benedetto A, Romano G, Bonvissuto G, Castelli T, Macchione

L, Magno C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus

selenium and lycopene (Profluss) versus S. repens alone: an Italian randomized multicentercontrolled study.

Urol Int 2010; 84: 400- 406.
Maneesh M, Jayalekshmi H, Dutta S, Chakrabarti A, Vasudevan DM. Effect of exogenous lecit- hin on

ethanolinduced testicular injuries in Wistar rats.Indian J Physiol Pharmacol. 2005 Jul- Sep;49(3):297-304.
Shimizu M, Weinstein IB. Modulation of signal transduction by tea catechins and related phytochemi- cals. Mutat
Res 2005; 225: 147-160.
Gerhauser C. Beer constituents as potential cancer chemopreventive agents. Eur J Cancer 2005; 41: 1941-1954.

Hijazi, M.M., Khatoon, N., Azmi, M.A., Rajput, M.T., Zaidi, S.I., Azmi, M.A., Perveen, R., Naqvi, S.N., Ras- hid, M., 2015.
Report: effects of Camellia sinensis L. (green tea) extract on the body and testicular weight changes in adult
Wistar rate. Pak. J. Pharm. Sci. 28, 249–253.
De Amicis, F., Santoro, M., Guido, C., Russo, A., Aquila, S., 2012. Epigallocatechin gallate affects survival and

metabolism of human sperm. Mol. Nutr. Food Res. 56, 1655–1664
Diaz JR, De Las Cagigas A, Rodriguez R. Micronutrient deficiencies in developing and affluent countries. Eur J Clin
Nutr 2003; 57 (Suppl.): S70–72.
Hinton BT, White RW, Setchell BP. Concentrations of myoinositol in the luminal fluid of the mammalian testis and
epididymis. J Reprod Fertil 1980; 58: 395–399.
Ponchia R, Bruno A, Renzi A, Landi C, Shaba E, Luongo FP, Haxhiu A, Artini PG, Luddi A, Governini L, Piomboni
P. Oxidative Stress Measurement in Frozen/Thawed Human Sperm: The Protective Role of an In Vitro

Treatment with Myo- Inositol. Antioxidants (Basel). 2021 Dec 22;11(1):10.
Ghasemi A, Amjadi F, Masoumeh Ghazi Mirsaeed S, Mohammad Beigi R, Ghasemi S, Moradi Y, Tahereh Ghazi
Mirsaeed S. The effect of Myo-inositol on sperm parameters and pregnancy rate in oligo- asthenospermic
men treated with IUI: A randomized clinical trial. Int J Reprod Biomed. 2019 Nov 7;17(10):749-756.
Russo GL, Russo M, Spagnuolo C, et al. Quercetin: a pleiotropic ki- nase inhibitor against cancer. Cancer Treat
Res. 2014;159:185-205.
Bharti S, Misro MM, Rai U. Quercetin supplementation restores testicular function and augments germ

cell survival in the estroge- nized rats. Mol Cell Endocrinol. 2014;383:10-20.
Ebokaiwe AP, Farombi EO. Influence of vitamin E and quercetin on Nigerian bonny light crude oil-indu- ced

neuronal and testicular tox- icity in wistar rats. J Basic Clin Physiol Pharmacol. 2015;26:223-231.
Diao R, Gan H, Tian F, Cai X, Zhen W, Song X, Duan YG. In vitro antioxidation effect of Querce- tin on sperm

function from the infertile patients with leukocytospermia. Am J Reprod Immunol. 2019 Sep;82(3):e13155.
Zohreh Nasiri, Fatemeh Ghorbani, Mohammad Seify, Aysan Sharbati. Effect of aqueous Nigella sativa extract on
the functional parameters of post-thaw human spermatozoa during vitrification. Clin Exp Reprod Med. 2022
Jun;49(2):110-116.
Rahman SA, Shaik Dawood NF, Basha SS, Kamarzaman S. Protective effect of black seed Nigella sativa (L.) against
cyclophosphamide-induced toxicity on reproductive and acrosomal function in mice. Middle East J Sci Res
2013;17:955– 64.
Kohestani Y, Kohestani B, Shirmohamadi Z, Roushandeh AM, Faghani M. The protective properties of

hydroalcoholic extract of Nigella sativa on male reproductive system in type 2 diabetes rats. Health Biotechnol
Biopharm 2019;3:45–56.
M. Kolahdooz, S. Nasri, S. Zadeh Modarres, S. Kianbakht, H. Fallah Huseini. Effects of Nigella sativa L. seed oil
on abnormal semen quality in infertile men: A randomized, double-blind, placebo controlled clinical trial.
Phytomedicine. 2014 May 15;21(6):901-5.
Behnaz Khani, Soroor Rabbani Bidgoli, Fariborz Moattar, Hassan Hassani. Effect of sesame on sperm quality of
infertile men. J Res Med Sci. 2013 Mar; 18(3): 184–187.
Gonzalez-Ravina C, Aguirre-Lipperheide M, Pinto F, Martin-Lozano D, Fernandez-Sanchez M, Blasco V, Santamaria-

Lopez E & Candenas L. Effect of dietary supplementation with a highly pure and concentrated docosahexaenoic

acid (DHA) supplement on human sperm function. Reprod Biol. 2018 18, 282–288.
R E Akhigbe, M A Hamed, A F Odetayo, T M Akhigbe, A F Ajayi, F A H Ajibogun. Omega-3 fatty acid rescues

ischaemia/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine
oxidase/uric acid signaling. Biomed Pharmacother. 2021 Oct;142:111975.
A-M L Falsig, C S Gleerup, U B Knudsen. The influence of omega-3 fatty acids on semen quality markers: a

systematic PRISMA review. Andrology. 2019 Nov;7(6):794-803.
S. Terés, G. Barceló-Coblijn, M. Benet, R. Álvarez, R. Bressani, J. E. Halver, and P. V. Escribá. Oleic acid content is
responsible for the reduction in blood pressure induced by olive oil. Proc Natl Acad Sci U S A. 2008 Sep 16;
105(37): 13811–13816.
Sima Sanagoo, Azizeh Farshbaf-Khalili, Parina Asgharian, Samad Hazhir, Behnaz Sadeghzadeh Oskouei.

Comparison of the effect of Ceratonia siliqua L. fruit oral capsule and vitamin E on semen parameters in men
with idiopathic infertility: a triple-blind randomized controlled clinical trial. J Complement Integr Med. 2021
Jul 26;18(4):791-796.
Mir Mohammad Reza Aghajani, Soleiman Mahjoub, Faraz Mojab, Mahshid Namdari, Neda Mahdinezhad Gorji,
Afsaneh Dashtaki, Parvaneh Mirabi. Comparison of the Effect of Ceratonia siliqua L. (Carob) Syrup and Vitamin

E on Sperm Parameters, Oxidative Stress Index, and Sex Hormones in Infertile Men: a Randomized
Controlled Trial. Reprod Sci. 2021 Mar;28(3):766-774.

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